The chronic use of drugs and alcohol damages:

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(A) Chronic use of drugs and alcohol has severe adverse effects on the human body.$1$. The $Nervous system$ is primarily affected by drugs, leading to

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Nervous system and liver

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(A) Chronic use of drugs and alcohol has severe adverse effects on the human body.$1$. The $Nervous system$ is primarily affected by drugs, leading to impaired cognitive functions, addiction, and behavioral changes.$2$. The $Liver$ is the primary organ responsible for the detoxification of alcohol and drugs. Prolonged exposure leads to conditions like cirrhosis, fatty liver, and hepatitis.Therefore, the most significant damage occurs in the $Nervous system$ and the $Liver$.

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