Phenylketonuria (PKU) is an inborn error of m | vedclass

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(C) Phenylketonuria $(PKU)$ is an inborn error of metabolism.It is caused by a mutation in the gene that codes for the enzyme phenylalanine hydroxylas

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Tyrosine,Autosomal recessive disorder

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(C) Phenylketonuria $(PKU)$ is an inborn error of metabolism.It is caused by a mutation in the gene that codes for the enzyme phenylalanine hydroxylase.In affected individuals,the enzyme phenylalanine hydroxylase is deficient or absent.This enzyme is responsible for converting the amino acid phenylalanine into tyrosine.Due to the lack of this enzyme,phenylalanine accumulates and is converted into phenylpyruvic acid and other derivatives,which leads to mental retardation.Since the gene responsible for this condition is located on an autosome and is expressed only in the homozygous recessive state $(pp)$,it is classified as an autosomal recessive disorder.

Column-$I$	Column-$II$
$(P)$ Haemophilia	$(i)$ Recessive gene: $X^{h}X^{h}$
$(Q)$ Colour blindness	$(ii)$ Recessive gene: $pp$
$(R)$ Phenylketonuria	$(iii)$ Recessive gene: $Hb^{s}Hb^{s}$
$(S)$ Sickle-cell anaemia	$(iv)$ Recessive gene: $X^{c}X^{c}$

Phenylketonuria $(PKU)$ is an inborn error of metabolism caused by the expression of recessive genes $(pp)$. In this condition,the amino acid phenylalanine is not converted into which amino acid,and what type of genetic disorder is it?

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