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(C) Malaria is caused by the protozoan parasite $Plasmodium$. When the $Plasmodium$ parasite infects human red blood cells $(RBCs)$,it undergoes asexu

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Hemozoin

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(C) Malaria is caused by the protozoan parasite $Plasmodium$. When the $Plasmodium$ parasite infects human red blood cells $(RBCs)$,it undergoes asexual reproduction. During this process,the parasite releases a toxic substance called $Hemozoin$ into the bloodstream. This release of $Hemozoin$ is responsible for the characteristic chills and high fever that recur every three to four days in malaria patients.

Column-$I$	Column-$II$
$(a)$ Pre-erythrocytic cycle	$(1)$ Meta-cryptomerozoites enter $RBC$ and become spherical in shape.
$(b)$ Exo-erythrocytic cycle	$(2)$ Sporozoites in saliva are introduced into human blood.
$(c)$ Endo-erythrocytic cycle	$(3)$ Breaks the liver cells and comes out into the blood.

Which toxic substance is responsible for the symptoms of malaria?

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