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(B) The rejection of a transplanted organ is primarily a result of the recipient's immune system recognizing the donor tissue as 'non-self'.$1$. The p

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Cell-Mediated Immunity

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(B) The rejection of a transplanted organ is primarily a result of the recipient's immune system recognizing the donor tissue as 'non-self'.$1$. The primary mechanism involved in organ rejection is $Cell-Mediated Immunity$ $(CMI)$.$2$. $T$-lymphocytes (specifically $T$-cytotoxic cells) recognize the foreign antigens on the surface of the transplanted organ cells.$3$. These $T$-cells then attack and destroy the donor cells, leading to tissue damage and organ rejection.$4$. While humoral immunity (antibodies) can also play a role, $Cell-Mediated Immunity$ is the dominant force in both acute and chronic rejection processes.

Which type of immune response is primarily responsible for the chronic rejection of a transplanted organ by the recipient?

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