CML (Chronic Myelogenous Leukemia) is caused | vedclass

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(B) Chronic Myelogenous Leukemia $(CML)$ is a type of cancer that affects the blood-forming cells in the bone marrow.It is characteristically associat

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Chromosomes $9$ and $22$

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(B) Chronic Myelogenous Leukemia $(CML)$ is a type of cancer that affects the blood-forming cells in the bone marrow.It is characteristically associated with a specific chromosomal abnormality known as the Philadelphia chromosome.This abnormality is formed by a reciprocal translocation between the long arms of chromosome $9$ and chromosome $22$,denoted as $t(9;22)(q34;q11)$.This translocation results in the fusion of the $BCR$ gene on chromosome $22$ with the $ABL1$ gene on chromosome $9$,creating the $BCR-ABL1$ fusion gene,which produces a constitutively active tyrosine kinase that drives uncontrolled cell proliferation.

$CML$ (Chronic Myelogenous Leukemia) is caused by the reciprocal translocation of which chromosomes?

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