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(D) The first recombinant $DNA$ $(r-DNA)$ was constructed by Stanley Cohen and Herbert Boyer in $1972$. They isolated an antibiotic resistance gene fr

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Antibiotic resistance gene

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(D) The first recombinant $DNA$ $(r-DNA)$ was constructed by Stanley Cohen and Herbert Boyer in $1972$. They isolated an antibiotic resistance gene from the plasmid of the bacterium $Salmonella typhimurium$ and linked it with a native plasmid of $Escherichia coli$ using the enzyme $DNA$ ligase. This allowed the antibiotic resistance gene to be replicated and expressed in the host $E. coli$ cells.

What was linked with the plasmid in the construction of the first $r-DNA$?

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