Which of the following hormones never enters the cytoplasm of the target cell?

Which of the following hormones is not a polypeptide?

Sex hormones function without the help of which of the following?

Which of the following is not necessarily a property of all hormones?

Given below are two statements: one is labelled as Assertion $(A)$ and the other is labelled as Reason $(R)$.
Assertion $(A)$: $FSH$,which interacts with membrane-bound receptors,does not enter the target cell.
Reason $(R)$: Binding of $FSH$ to its receptors generates a second messenger (cyclic $AMP$) for its biochemical and physiological responses.
In the light of the above statements,choose the most appropriate answer from the options given below:

Which of the following statements is correct regarding the endocrine system?