In sickle cell anemia - | vedclass

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Question

(A) Sickle cell anemia is an autosome-linked recessive trait. It is caused by a point mutation in the gene coding for the $\beta$-globin chain of hemo

Vedclass · Accepted Answer

Mutant hemoglobin molecules undergo polymerization under low oxygen tension,causing the change in the shape of the $RBC$.

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(A) Sickle cell anemia is an autosome-linked recessive trait. It is caused by a point mutation in the gene coding for the $\beta$-globin chain of hemoglobin. Specifically,the amino acid glutamic acid at the sixth position of the $\beta$-globin chain is replaced by valine. Due to this substitution,the mutant hemoglobin molecule undergoes polymerization under low oxygen tension,which causes the $RBC$ to change its shape from a biconcave disc to an elongated sickle-like structure.

In sickle cell anemia -

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