Which of the following mutagens causes frame- | vedclass

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(B) Frame-shift mutations are caused by the insertion or deletion of one or more nucleotide base pairs in a $DNA$ sequence,which shifts the reading fr

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Proflavin

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(B) Frame-shift mutations are caused by the insertion or deletion of one or more nucleotide base pairs in a $DNA$ sequence,which shifts the reading frame of the genetic message.Proflavin is an acridine dye that acts as an intercalating agent.It inserts itself between the stacked base pairs of the $DNA$ double helix,which often leads to the addition or deletion of base pairs during $DNA$ replication,thereby causing frame-shift mutations.In contrast,$2$-Aminopurine and $5$-Bromouracil are base analogs that cause base-pair substitution mutations,not frame-shift mutations.Methane sulfonates are alkylating agents that also typically cause base-pair substitutions.

Which of the following mutagens causes frame-shift mutations?

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