Which of the following is a mitotic poison?

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(D) mitotic poison is a substance that interferes with the process of mitosis. $1$. Colchicine inhibits the formation of spindle fibers by binding to

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All of the above

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(D) mitotic poison is a substance that interferes with the process of mitosis. $1$. Colchicine inhibits the formation of spindle fibers by binding to tubulin,preventing the separation of chromosomes during anaphase. $2$. Mustard gas and Azides are known to interfere with cellular metabolism and $DNA$ synthesis,thereby arresting the cell cycle. $3$. Cyanides inhibit cellular respiration by blocking the electron transport chain,which deprives the cell of the energy $(ATP)$ required for division. Therefore,all the listed substances act as mitotic poisons.

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