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(B) : Alzheimer's disease is a neurological disorder characterized by the progressive loss of intellectual ability.This disease,named after the German

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acetylcholine

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(B) : Alzheimer's disease is a neurological disorder characterized by the progressive loss of intellectual ability.This disease,named after the German physician Alois Alzheimer $(1864-1915)$,is associated with the general shrinkage of brain tissue.It involves the accumulation of $\beta$-amyloid protein deposits and abnormal filaments composed of tau protein in the brain.Furthermore,it involves changes in the neurotransmitter systems,specifically a significant reduction in the activity of cholinergic neurons,which are neurons that release the neurotransmitter acetylcholine.Some inherited forms of the disease are linked to a genetic locus on chromosome $21$.

Alzheimer's disease in humans is associated with the deficiency of

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