Besides better aeration and mixing properties,what other advantages do stirred tank bioreactors have over shake flasks?

(N/A) Shake flasks are used for growing and mixing the desired materials on a small scale in the laboratory. $A$ large-scale production of desired biotechnological products is done by using $bioreactors$. Besides better aeration and mixing properties,the bioreactors have the following advantages:
$(i)$ Small volumes of cultures can be periodically withdrawn from the bioreactor for sampling.
$(ii)$ They have a foam control system,a pH control system,and a temperature control system to regulate the environment during the process.
$(iii)$ They facilitate even mixing and oxygen availability throughout the bioreactor with the help of baffles.