(D) Cardiac output is defined as the volume of blood pumped by the heart per minute.It is calculated by the product of stroke volume and heart rate.Ma

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(D) Cardiac output is defined as the volume of blood pumped by the heart per minute.It is calculated by the product of stroke volume and heart rate.Mathematically, $\text{Cardiac Output} = \text{Stroke Volume} \times \text{Heart Rate}$.Therefore, both heart rate and stroke volume determine the cardiac output.