Discuss the process of translation in detail.

Vedclass pdf generator app on play store
Vedclass iOS app on app store
(N/A) Translation refers to the process of polymerisation of amino acids to form a polypeptide. Ribosome is the site of protein synthesis. The amino acids are joined by a bond which is known as a peptide bond. Formation of a peptide bond requires energy. Therefore,in the first phase itself,amino acids are activated in the presence of $ATP$ and linked to their respective $tRNA$—a process commonly called activation or charging of $tRNA$,or aminoacylation of $tRNA$ to be more specific.
If two such charged $tRNAs$ are brought close enough,the formation of a peptide bond between them would be favoured energetically. The presence of a catalyst would enhance the rate of peptide bond formation. The cellular factory responsible for synthesising proteins is the ribosome. The ribosome consists of structural $RNAs$ and about $80$ different proteins. In its inactive state,it exists as two subunits: a large subunit and a small subunit.
When the small subunit encounters an $mRNA$,the process of translation of the $mRNA$ to protein begins. There are two sites in the large subunit for subsequent amino acids to bind to and thus be close enough to each other for the formation of a peptide bond. The ribosome also acts as a catalyst ($23S$ $rRNA$ in bacteria is the enzyme-ribozyme) for the formation of a peptide bond.
$A$ translational unit in $mRNA$ is the sequence of $RNA$ that is flanked by the start codon $(AUG)$ and the stop codon and codes for a polypeptide. An $mRNA$ also has some additional sequences that are not translated and are referred to as untranslated regions $(UTR)$. The $UTRs$ are present at both $5^{\prime}$-end (before start codon) and at $3^{\prime}$-end (after stop codon). They are required for efficient translation process.
For initiation,the ribosome binds to the $mRNA$ at the start codon $(AUG)$ that is recognised only by the initiator $tRNA$. The ribosome proceeds to the elongation phase of protein synthesis. During this stage,complexes composed of an amino acid linked to $tRNA$ sequentially bind to the appropriate codon in $mRNA$ by forming complementary base pairs with the $tRNA$ anticodon. The ribosome moves from codon to codon along the $mRNA$.

Explore More

Similar Questions

$A$ polypeptide of five amino acids is synthesized during protein synthesis in eukaryotic cells. Which one of the following can be the correct polypeptide?

Which one of the following also acts as a catalyst in a bacterial cell?

If an $mRNA$ has the codon $UAG$,which anticodon will the incoming $tRNA$ carry?

Which of the following is not a part of the translation unit?

In which process does the transfer of genetic information occur?

Vedclass Products

For Students

Vedclass Test Series

Mock tests in real JEE/NEET style with performance analysis. 5-day free trial.

Start Free Trial
For Teachers

Exam Paper Generator

Generate Set A/B/C/D exam papers from 7.5L+ questions in 2 minutes. 3 chapters free.

Try Free
For Institutes

Online Exam Module

Live online exams with unlimited students, 360° analytics & white-label branding.

See Demo