During glycolysis,the enzyme hexokinase conve | vedclass

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Question

(A) In glycolysis,hexokinase catalyzes the phosphorylation of glucose to glucose-$6$-phosphate. Glucose-$6$-phosphate acts as an allosteric inhibitor

Vedclass · Accepted Answer

Feedback inhibition

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(A) In glycolysis,hexokinase catalyzes the phosphorylation of glucose to glucose-$6$-phosphate. Glucose-$6$-phosphate acts as an allosteric inhibitor of the enzyme hexokinase. This is a classic example of feedback inhibition (or end-product inhibition),where the product of a metabolic pathway inhibits an enzyme that acts early in the pathway to regulate the flux of the reaction and prevent the over-accumulation of the product.

During glycolysis,the enzyme hexokinase converts glucose to glucose-$6$-phosphate. The activity of hexokinase is inhibited by glucose-$6$-phosphate through which of the following mechanisms?

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