Fever in malaria is due to

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(C) In malaria,the fever is caused by the release of a toxic substance called $hemozoin$ from the infected red blood cells $(RBCs)$.When the $Plasmodi

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Release of merozoites from red blood cells

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(C) In malaria,the fever is caused by the release of a toxic substance called $hemozoin$ from the infected red blood cells $(RBCs)$.When the $Plasmodium$ parasite completes its erythrocytic cycle,the $RBCs$ rupture to release the merozoites into the bloodstream.Along with the merozoites,the $hemozoin$ toxin is also released,which triggers the release of cytokines and causes the characteristic chills and high fever associated with malaria.

Column-$I$	Column-$II$
$(a)$ Pre-erythrocytic cycle	$(1)$ Meta-cryptomerozoites enter $RBC$ and become spherical in shape.
$(b)$ Exo-erythrocytic cycle	$(2)$ Sporozoites in saliva are introduced into human blood.
$(c)$ Endo-erythrocytic cycle	$(3)$ Breaks the liver cells and comes out into the blood.

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