Glucose and mannose are

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(D) Glucose and mannose differ in configuration at the $C-2$ carbon atom. Such diastereomers that differ in configuration at only one stereocenter are

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Epimers

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(D) Glucose and mannose differ in configuration at the $C-2$ carbon atom. Such diastereomers that differ in configuration at only one stereocenter are known as epimers. Therefore,glucose and mannose are $C-2$ epimers.

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