Haemoglobin $(Hb)$ transports oxygen from the lungs to tissues. The partial pressure of oxygen in the lungs is different from that in the tissues. Each $Hb$ can bind to up to four oxygen molecules. Suppose we have an equal number of $Hb$ and oxygen molecules,and all the oxygen molecules are in a bound form. Then,which of the following is true?

  • A
    Almost all the $Hb$ molecules have one bound oxygen molecule.
  • B
    Nearly half of all the $Hb$ molecules are bound to two oxygen molecules.
  • C
    Nearly one-fourth of all the $Hb$ molecules are bound to four oxygen molecules each.
  • D
    Most of the $Hb$ molecules have one bound oxygen molecule each; the rest either have no bound oxygen or have two or more bound oxygen molecules.

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People living at sea level have around $5 \; million$ $RBCs$ per cubic millimetre of their blood,whereas those living at an altitude of $5400 \; m$ have around $8 \; million$. This is because at high altitude:

With reference to the oxyhaemoglobin dissociation curve,select the $INCORRECT$ statement/statements.
$I$. $100\%$ saturation is very common.
$II$. $95-97\%$ saturation takes place at $ppO_2 = 100 \text{ mm Hg}$ in alveoli.
$III$. At $30 \text{ mm Hg}$ of $ppO_2$,only $50\%$ saturation can be maintained.
$IV$. The oxyhaemoglobin dissociation curve is $J$-shaped.
Select the correct option.

If $ppCO_2$ is high and pH is low,then it will result in:
$i$. increase in affinity of haemoglobin for $O_2$
$ii$. decrease in affinity of haemoglobin for $O_2$
$iii$. oxygen dissociation curve shifts to left
$iv$. causes release of $O_2$ for diffusion into tissue cells
$v$. $H^+$ and $HCO_3^-$ ions combine to form carbonic acid

Which of the following combines irreversibly with blood haemoglobin?

Which of the following factors affect the binding of oxygen with hemoglobin?

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