In gene therapy of adenosine deaminase text{( | vedclass

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Question

(D) In the gene therapy for $	ext{ADA}$ deficiency,functional $	ext{ADA}$ $	ext{cDNA}$ is introduced into the patient's lymphocytes using a retrovi

Vedclass · Accepted Answer

Genetically engineered lymphocytes are not immortal cells.

Vedclass · Answer

(D) In the gene therapy for $	ext{ADA}$ deficiency,functional $	ext{ADA}$ $	ext{cDNA}$ is introduced into the patient's lymphocytes using a retroviral vector. These genetically engineered lymphocytes are then reintroduced into the patient. However,these lymphocytes are not immortal,meaning they have a finite lifespan and eventually die. Therefore,the patient requires periodic infusions of these genetically engineered cells to maintain the production of the $	ext{ADA}$ enzyme.

In gene therapy of adenosine deaminase $\text{(ADA)}$ deficiency,the patient requires periodic infusion of genetically engineered lymphocytes because:

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