Which of the following is known as the natural genetic engineer?

Match the following columns:

Column-$I$	Column-$II$
$(a) \ Cla \ I$	$(1) \ \text{Antibiotic resistance gene}$
$(b) \ pBR322$	$(2) \ \text{Origin of replication}$
$(c) \ tet^R$	$(3) \ \text{Restriction enzyme}$
$(d) \ ori$	$(4) \ \text{Plasmid}$

Which of these enzymes is required to cleave a plasmid?

Discuss with your teacher and find out how to distinguish between (Any two):
$(a)$ Plasmid $DNA$ and Chromosomal $DNA$
$(b)$ $RNA$ and $DNA$
$(c)$ Exonuclease and Endonuclease

Identify the incorrect statement with regard to Restriction Enzymes.

In the gel electrophoresis method . . . . . . .