Replacement of which one of the following nuc | vedclass

Name: Exam Paper Generator | JEE NEET Paper Generator | Vedclass
Brand: Vedclass
Rating: 5 (35 reviews)

Question

(A) Sickle cell anaemia is caused by a point mutation in the $Hb^A$ gene.Specifically,a single nucleotide substitution occurs in the $DNA$ sequence wh

Vedclass · Accepted Answer

$A$ to $T$

Vedclass · Answer

(A) Sickle cell anaemia is caused by a point mutation in the $Hb^A$ gene.Specifically,a single nucleotide substitution occurs in the $DNA$ sequence where the nucleotide $Adenine$ $(A)$ is replaced by $Thymine$ $(T)$.This mutation changes the codon $GAG$ to $GTG$ at the sixth position of the $\beta$-globin chain.Consequently,the amino acid $Glutamic$ $acid$ is replaced by $Valine$ at the sixth position of the hemoglobin protein,leading to the formation of abnormal $Hb^S$ hemoglobin.

Replacement of which one of the following nucleotides in the $Hb^A$ gene causes sickle cell anaemia?

Similar Questions

Mutations caused by mutagenic agents are termed as

Point mutation is a change which involves

Mutation is induced by ...........

Select the appropriate option for mutation.

Haploids are more suitable for mutation studies than diploids. This is because

Vedclass Test Series

Exam Paper Generator

Online Exam Module