The amino acid substituted in sickle cell ana | vedclass

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Question

(D) In sickle cell anaemia,a point mutation occurs in the gene coding for the $\beta$-globin chain of haemoglobin.Specifically,the sixth amino acid of

Vedclass · Accepted Answer

Valine for glutamic acid in the beta chain

Vedclass · Answer

(D) In sickle cell anaemia,a point mutation occurs in the gene coding for the $\beta$-globin chain of haemoglobin.Specifically,the sixth amino acid of the normal $\beta$-globin chain,which is glutamic acid,is replaced by valine.This substitution occurs due to a single base pair change ($GAG$ to $GUG$) in the $DNA$ sequence.Therefore,the correct substitution is valine for glutamic acid in the $\beta$-chain.

The amino acid substituted in sickle cell anaemia is

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