The diagram below shows:

  • A
    Maturation of pro-insulin into insulin
  • B
    Method of pro-insulin formation
  • C
    Gene therapy
  • D
    Enzyme replacement therapy

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Why would the $lac Z$ gene be fused to the coding sequence of chain $A$ and $B$ in plasmids of $E. coli$?

Which of the following is/are correct about Adenosine Deaminase $(ADA)$ deficiency?
$I$. In the absence of adenosine deaminase enzyme,purine metabolism is disturbed and $T$-lymphocytes fail to function.
$II$. $ADA$ deficiency is caused by the deletion of the gene for $ADA$.
$III$. In some cases,it can be cured by bone marrow transplantation and enzyme replacement therapy. But in both approaches,the patients are not completely cured.
$IV$. For permanent cure,genes isolated from the bone marrow cells producing $ADA$ at early embryonic stages can be a possible cure.
Which of the above statements are correct?

$ADA$ deficiency results in

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