The classical example of point mutation is

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(B) Step $1$: Point mutation is a genetic mutation where a single nucleotide base is changed, inserted, or deleted from a $DNA$ or $RNA$ sequence.Step

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Sickle cell anaemia

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(B) Step $1$: Point mutation is a genetic mutation where a single nucleotide base is changed, inserted, or deleted from a $DNA$ or $RNA$ sequence.Step $2$: Sickle cell anaemia is caused by a single base pair substitution in the gene for $ \beta $-globin chain of haemoglobin, where $ GAG $ is replaced by $ GUG $ at the sixth codon position.Step $3$: This leads to the substitution of glutamic acid with valine, making it a classic example of point mutation.

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$(i)$ Due to alteration of $DNA$ sequences,the genotype is changed.
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