The critical research areas of biotechnology are:
$I$. Providing the best catalyst as an improved organism,usually a microbe or pure enzyme.
$II$. Creating optimal conditions through engineering for a catalyst to act.
$III$. Downstream processing technologies.
$IV$. Multiple Ovulation Embryo Transfer Technology $(MOET)$.
Which of the statements given above are correct?

• A
  $I$ and $II$
• B
  $I$,$II$ and $III$
• C
  $II$,$III$ and $IV$
• D
  $I$,$II$,$III$ and $IV$