The following reaction represents:alpha-ketog | vedclass

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$(A)$ The organic acid, $\alpha$-ketoglutaric acid, plays a key role in the synthesis of amino acids.In this process, ammonia $(NH_{4}^{+})$ formed by

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Reductive amination

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$(A)$ The organic acid, $\alpha$-ketoglutaric acid, plays a key role in the synthesis of amino acids.In this process, ammonia $(NH_{4}^{+})$ formed by nitrogen assimilation reacts with $\alpha$-ketoglutaric acid to form an amino acid, i.e., glutamic acid (glutamate).This reaction is catalyzed by the enzyme glutamate dehydrogenase.Since the reaction involves the addition of an amino group and the reduction of the substrate using $NADPH$, it is known as reductive amination.

The following reaction represents:
$\alpha$-ketoglutaric acid $+ NH_{4}^{+} + NADPH \xrightarrow{\text{Glutamate dehydrogenase}} \text{Glutamate} + H_{2}O + NADP$

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$\alpha$-Ketoglutaric acid + $NH_4^+ + NADPH \rightarrow$ Glutamate + $H_2O + NADP$

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The following reaction represents:$\alpha$-ketoglutaric acid $+ NH_{4}^{+} + NADPH \xrightarrow{\text{Glutamate dehydrogenase}} \text{Glutamate} + H_{2}O + NADP$