Which of the following fungi produces $Cyclosporin \ A$,which is used as an immunosuppressive agent in organ-transplant patients?

$A$: Myocardial infarction can now be treated more effectively due to genetic engineering.
$R$: Streptokinase produced by $Streptococcus$ and modified by $RDT$ is used as a clot buster for removing thrombus.

Streptokinase produced by the bacterium $Streptococcus$ is used for:

Match the following columns:

Column-$I$	Column-$II$
$(a)$ Streptococcus	$(1)$ Alcoholic beverages
$(b)$ Monascus purpureus	$(2)$ Streptokinase
$(c)$ Trichoderma polysporum	$(3)$ Statins
$(d)$ Saccharomyces cerevisiae	$(4)$ Cyclosporin $A$

Cells in a continuous culture system are maintained in:

$A$ enzyme is used to remove clots from the blood vessels of patients who have undergone $B$ leading to heart attack.