Which of the following is most reactive towar | vedclass

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(C) The reactivity of alkyl halides toward $S_{N}2$ reactions depends on the steric hindrance and the stability of the transition state. $S_{N}2$ reac

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$Me-O-CH_2-Cl$

Vedclass · Answer

(C) The reactivity of alkyl halides toward $S_{N}2$ reactions depends on the steric hindrance and the stability of the transition state. $S_{N}2$ reactions are favored by less steric hindrance and electron-withdrawing groups that stabilize the transition state. In $Me-O-CH_2-Cl$,the oxygen atom has lone pairs that can stabilize the transition state through resonance (or the inductive effect of the oxygen atom),making it highly reactive. Specifically,$\alpha$-halo ethers are known to be extremely reactive in $S_{N}2$ reactions due to the stabilization of the transition state by the adjacent oxygen atom. Therefore,$Me-O-CH_2-Cl$ is the most reactive toward $S_{N}2$ reaction.

Which of the following is most reactive toward $S_{N}2$ reaction?

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