Which substances when present in high level can activate the chemosensitive area present adjacent to the rhythm centre?

  • A
    $CO_2$ and $O_2$
  • B
    $HCO_3^-$ ions and $O_2$
  • C
    $CO_2$ and $H^+$ ions
  • D
    $H^+$ and $HCO_3^-$ ions

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