If the mother has a genotype of Hb^{A}Hb^{S} | vedclass

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(D) Sickle cell anemia is an autosomal recessive disorder.Both parents are carriers $(Hb^{A}Hb^{S} 	imes Hb^{A}Hb^{S})$.The Punnett square for this c

Vedclass · Accepted Answer

$12.5$

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(D) Sickle cell anemia is an autosomal recessive disorder.Both parents are carriers $(Hb^{A}Hb^{S} 	imes Hb^{A}Hb^{S})$.The Punnett square for this cross results in:- $Hb^{A}Hb^{A}$ (Normal): $25 \%$- $Hb^{A}Hb^{S}$ (Carrier): $50 \%$- $Hb^{S}Hb^{S}$ (Affected): $25 \%$The probability of having an affected child $(Hb^{S}Hb^{S})$ is $1/4$ or $25 \%$.Since the question asks for the probability of having an affected son,we must consider the probability of the child being male $(1/2)$ and the probability of the child being affected $(1/4)$.Probability = $P(	ext{Affected}) 	imes P(	ext{Male}) = 1/4 	imes 1/2 = 1/8$ or $12.5 \%$.

If the mother has a genotype of $Hb^{A}Hb^{S}$ and the father has a genotype of $Hb^{A}Hb^{S}$,what is the probability of having an affected son (in $\%$)?

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