Why are genetically engineered lymphocytes pe | vedclass

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Question

(D) Step $1$: In the treatment of $ADA$ (Adenosine Deaminase) deficiency, lymphocytes are extracted from the patient's blood and a functional $ADA$ ge

Vedclass · Accepted Answer

Both $A$ and $C$.

Vedclass · Answer

(D) Step $1$: In the treatment of $ADA$ (Adenosine Deaminase) deficiency, lymphocytes are extracted from the patient's blood and a functional $ADA$ gene is introduced into them.Step $2$: These genetically engineered cells are not immortal and have a limited lifespan, meaning they eventually die.Step $3$: Additionally, in the context of this specific therapeutic approach, the introduced gene may be lost from the population of cells over time.Step $4$: Therefore, to provide continuous treatment, these genetically engineered lymphocytes must be periodically reintroduced into the patient's body. Thus, the correct option is $D$.

Why are genetically engineered lymphocytes periodically introduced into the patient in the treatment of $ADA$ deficiency?

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