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(C) The first biochemical produced commercially using microbial cloning and genetic engineering is $Human 	ext{ } insulin$ (also known as $Humulin$).

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Human insulin

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(C) The first biochemical produced commercially using microbial cloning and genetic engineering is $Human 	ext{ } insulin$ (also known as $Humulin$).In $1978$, scientists at Genentech successfully synthesized the two $DNA$ sequences corresponding to the $A$ and $B$ chains of human insulin and introduced them into $E. 	ext{ } coli$ plasmids to produce the hormone.This marked a significant milestone in biotechnology, as it provided a safe and abundant source of insulin for diabetic patients, replacing the previously used insulin extracted from the pancreases of slaughtered cattle and pigs.

First biochemical to be produced commercially by microbial cloning and genetic engineering is:

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