Sickle cell anaemia is more common in certain | vedclass

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(A) Sickle cell anaemia is an autosomal recessive genetic disorder. It is caused by a point mutation in the gene encoding the $\beta$-globin chain of

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Change in $\beta$-chain of haemoglobin

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(A) Sickle cell anaemia is an autosomal recessive genetic disorder. It is caused by a point mutation in the gene encoding the $\beta$-globin chain of haemoglobin. Specifically,at the $6^{th}$ position of the $\beta$-globin chain,the amino acid glutamic acid is replaced by valine. This substitution leads to the formation of abnormal haemoglobin $(HbS)$,which causes red blood cells to become sickle-shaped under low oxygen tension.

Sickle cell anaemia is more common in certain regions due to evolutionary adaptations against malaria. The molecular basis of this disease is:

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