The defect sickle-cell anaemia is caused by t | vedclass

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(A) Sickle-cell anaemia is a point mutation caused by the substitution of a single nucleotide base in the gene coding for the $\beta$-globin chain of

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Substitution,$\beta$

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(A) Sickle-cell anaemia is a point mutation caused by the substitution of a single nucleotide base in the gene coding for the $\beta$-globin chain of haemoglobin.Specifically,at the $6^{th}$ position of the $\beta$-globin chain,the codon $GAG$ is replaced by $GUG$.This results in the substitution of glutamic acid with valine in the protein sequence.This change is a result of a transversion mutation where the nucleotide $A$ (adenine) is replaced by $T$ (thymine) in the $DNA$ sequence,leading to the change in the mRNA codon from $GAG$ to $GUG$.

The defect sickle-cell anaemia is caused by the . . . . . . of glutamic acid by valine at the $6^{th}$ position of the . . . . . . globin chain of the haemoglobin molecule.

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