The genetic defect-adenosine deaminase (ADA) | vedclass

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Question

(B) The correct answer is $(B)$.$ADA$ deficiency is caused by the deletion of the gene for adenosine deaminase.While enzyme replacement therapy and pe

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introducing bone marrow cells producing $ADA$ into cells at early embryonic stages

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(B) The correct answer is $(B)$.$ADA$ deficiency is caused by the deletion of the gene for adenosine deaminase.While enzyme replacement therapy and periodic infusion of genetically engineered lymphocytes are treatments,they are not permanent cures as they require repeated administration.$A$ permanent cure can be achieved by gene therapy,specifically by introducing the functional $ADA$ gene isolated from bone marrow cells into cells at early embryonic stages,which allows the gene to be present in all cells of the developing organism.

Column-$I$	Column-$II$
$(A)$ Gene therapy	$(1)$ Effort to fix a functional gene
$(B)$ Humulin	$(2)$ $A$ single-stranded $DNA$ or $RNA$ tagged with a radioactive molecule
$(C)$ Probe	$(3)$ Diagnostic test
$(D)$ $ELISA$	$(4)$ Diabetes

The genetic defect-adenosine deaminase $(ADA)$ deficiency may be cured permanently by

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Match the following columns.

Column-$I$ Column-$II$

$(A)$ Gene therapy $(1)$ Effort to fix a functional gene

$(B)$ Humulin $(2)$ $A$ single-stranded $DNA$ or $RNA$ tagged with a radioactive molecule

$(C)$ Probe $(3)$ Diagnostic test

$(D)$ $ELISA$ $(4)$ Diabetes

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