The order of decreasing rate of reaction with | vedclass

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(A) The rate of nucleophilic acyl substitution reaction depends on the leaving group ability and the electrophilicity of the carbonyl carbon.$1$. Anhy

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Anhydrides,esters,ethers

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(A) The rate of nucleophilic acyl substitution reaction depends on the leaving group ability and the electrophilicity of the carbonyl carbon.$1$. Anhydrides $(RCO-O-COR)$ are highly reactive because the carboxylate ion $(RCOO^-)$ is a good leaving group.$2$. Esters $(RCOOR')$ are less reactive than anhydrides because the alkoxide ion $(RO^-)$ is a poorer leaving group compared to the carboxylate ion.$3$. Ethers $(R-O-R')$ do not contain a carbonyl group and are generally inert towards nucleophilic attack by ammonia under standard conditions.Therefore,the decreasing order of reactivity is: $Anhydrides > Esters > Ethers$.

The order of decreasing rate of reaction with ammonia is:

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